For many people, GLP-1 medications like semaglutide and tirzepatide have been game-changers for appetite control and weight loss. These drugs mimic a natural hormone called GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar, improve insulin sensitivity, slow digestion, and signal fullness to the brain, making it easier to eat less and lose weight.

But what happens when you stop taking them? Appetite often returns, calorie intake tends to creep up, and blood sugar levels can rebound, making it harder to maintain progress.

Fortunately, certain nutrients and supplements may help you maintain the progress made on a GLP-1 medication (when combined with a balanced diet and regular exercise). Keep reading to find out which supplements and foods to consider. 

Note: Always consult a healthcare provider before starting any new supplement. 

#1: Dihydroberberine

Dihydroberberine (DHB) is an enhanced, more absorbable form of berberine—a natural plant compound often likened to metformin for its powerful insulin-supporting benefits. By activating AMPK, the body’s “metabolic master switch,” DHB helps balance blood sugar, improve insulin sensitivity, support appetite control, and encourage the body to use fat for energy. While its mechanism differs from GLP-1 drugs, DHB may offer similar metabolic advantages.

👉All dihydroberberine (DHB) used in supplements is sourced from GlucoVantage® by NNB Nutrition, the exclusive, lab-tested form shown to deliver five times more berberine to the bloodstream than standard berberine.

#2: Magnesium 

Magnesium is a powerhouse mineral involved in more than 300 enzymatic reactions, including those involved in glucose regulation. In fact, low magnesium levels have been linked to reduced insulin sensitivity and a higher risk of insulin resistance.

To keep magnesium levels optimal, include foods like leafy greens, almonds, pumpkin seeds, and whole grains in your diet, or consider a supplement if your intake tends to fall short.

#3: Akkermansia

Akkermansia muciniphila is a beneficial bacterium that naturally lives in the gut and plays a key role in metabolic health. Research links higher levels of Akkermansia to better weight management, improved glucose control, increased natural GLP-1 production, and a stronger gut barrier.

Taking a targeted Akkermansia probiotic supplement—or eating foods that feed beneficial gut bacteria—may help support metabolic health and gut balance after coming off a GLP-1 medication.

#4: Curcumin

Curcumin (the active compound in turmeric) has shown promise in supporting blood sugar regulation and overall metabolic health. A 2021 review found that curcumin may help lower blood glucose levels and reduce complications associated with diabetes. Researchers attribute these effects to curcumin’s strong antioxidant and anti-inflammatory properties. 

While you can boost intake through turmeric-rich foods or drinks, curcumin supplements are often needed to obtain meaningful levels. 

👉Look for supplements containing CurcuPrime®, a highly bioavailable, potent form of curcumin. 

#5: Healthy Fats, Lean Protein, and Fiber

A balanced diet rich in specific nutrients can help naturally support GLP-1 levels and overall metabolic health. Here’s what to focus on:

• Healthy fats: Monounsaturated and omega-3 fats from foods like avocado, olive oil, and fatty fish may help stimulate GLP-1 production and improve heart health.

• Lean protein: Protein from fish, poultry, eggs, tofu, or Greek yogurt helps maintain muscle mass and may naturally boost satiety and GLP-1 release.

• Soluble fiber: Found in fruits, vegetables, oats, beans, and seeds, soluble fiber slows digestion, steadies blood sugar, and increases GLP-1 levels.

Together, these foods help keep your metabolism steady, support appetite control, and make post-GLP-1 weight maintenance more achievable.

The Bottom Line

Ending GLP-1 therapy doesn’t have to mean losing your metabolic momentum. By prioritizing nutrients that promote glucose control, insulin sensitivity, and appetite control, you can help your body preserve the progress you’ve worked hard to achieve.

Written by Katie Koschalk, a health and wellness writer, certified holistic nutritionist, and certified personal trainer based in California.